How can obesity affect liver function?

Obesity has a significant impact on liver function, primarily through its association with non-alcoholic fatty liver disease (NAFLD). Excess body weight is a key risk factor for the accumulation of fat in liver cells, which can lead to the development of NAFLD. This condition is characterized by the excess fat deposition in the liver of individuals who do not consume excessive alcohol, and it can progress to more serious liver damage, including steatohepatitis, fibrosis, and even cirrhosis.

In individuals with obesity, insulin resistance is often present, leading to increased free fatty acids and triglycerides in the liver, which contributes to the pathophysiology of NAFLD. This condition is increasingly recognized as a major public health concern, as it can lead to significant morbidity, impacting hepatic function and overall health. Understanding this connection between obesity and liver health is crucial for preventive measures and management strategies.