What does hepatotoxicity refer to?

Hepatotoxicity specifically refers to damage to the liver that is caused by chemicals or drugs. The liver plays a critical role in metabolizing substances, including medications and toxins, and is particularly vulnerable to injury from these agents. When the hepatocytes (liver cells) are exposed to harmful substances, it can lead to inflammation, cellular damage, and in severe cases, liver failure. Understanding hepatotoxicity is essential for identifying potential adverse effects of medications and for monitoring liver function, especially in patients on long-term pharmacotherapy.

This focus on liver-related damage distinguishes it from other potential harms caused by substances, such as kidney damage or airway inflammation, which are associated with other body systems.