What is a common consequence of cholestasis?

The consequence of cholestasis includes the accumulation of bile in the liver. Cholestasis refers to the impaired flow of bile, leading to its buildup. This condition can occur due to various factors, such as obstructions in the bile ducts or liver dysfunction. When bile cannot be effectively secreted into the intestines, it starts to accumulate within the hepatocytes and bile canaliculi.

This accumulation can lead to liver injury and may manifest clinically as jaundice, pruritus, and other hepatic dysfunction symptoms. It is important to recognize that the accumulation of bile is detrimental, as the components of bile, including bile salts and bilirubin, can be toxic at elevated levels.

In contrast, reduction in bile salt absorption relates to the downstream effects of a compromised biliary system but is not a direct consequence of cholestasis itself. Increased appetite is typically not associated with cholestasis and can, in fact, be contrary to what patients experience, which can be reduced due to discomfort or nausea. Additionally, cholestasis does not enhance liver function; the accumulation of bile typically indicates a decline in function rather than an improvement.