What might occur if elevated alkaline phosphatase levels are not addressed?

Elevated alkaline phosphatase levels can indicate cholestasis or obstruction in the bile ducts, leading to an accumulation of bile acids and other substances that can be toxic to hepatobiliary structures. If these elevated levels are not addressed, the prolonged stress on hepatocytes, canalicular structures, and the biliary tree can result in inflammation, fibrosis, or even irreparable damage to liver and biliary tissues. This potential damage could ultimately progress to conditions such as cirrhosis or liver failure, highlighting the importance of monitoring and addressing the underlying causes of elevated alkaline phosphatase levels to prevent significant hepatobiliary damage.

In contrast, normal bile flow would not result from unaddressed elevated alkaline phosphatase; rather, it would likely remain compromised. The reduction in liver size and improved digestion of fats are not directly associated consequences of ongoing elevated alkaline phosphatase levels. Addressing the underlying causes of the elevation is crucial to maintaining biliary and liver health.